Comprehensive Chemistry and Biology of Coumarins Scaffold

Comprehensive Chemistry and Biology of Coumarins Scaffold covers detailed methods and protocols to synthetize Coumarin derivatives and different applications and future perspectives for these compounds. Coumarin-Based Scaffolds plays an important role in organic, bioorganic, and medicinal chemistry as they act as a bridge between chemistry, life sciences, and biochemical investigations. Coumarin is an important scaffold for designing, generating a wide variety of chemical libraries and drug-like candidates to obtain desired therapeutic and pharmacological properties. Specific functional groups are covered as well as the synthesis of bioactive compounds against specific pathological conditions. The discovery of new coumarin-based drug candidates during the last decades has been covered to assist the pharmaceutical, bioorganic and medicinal chemists for their further research on coumarin-based molecules. Provides a resource that is organized consistently based on targets and mechanisms of action from a molecular point-of-viewEmphasizes synthetic methodologies and their various medicinal applicationsCritically analyzes and updates much of the widely dispersed content in one place INDICE: 1. General Introduction of Coumarin 2. Progress in the Chemistry of Naturally Occurring Coumarins 3. Synthesis and Reactivity of Coumarin Derivatives 4. Recent Progress in the Coumarin-Based Marketed Drugs Development 5. Natural and Synthetic Coumarin Derivatives with Antimicrobial Activities 6. Coumarin as Multi-Targeted Scaffold in Medicinal Chemistry: Potential Anticancer Agents 7. Role of Coumarin and its Privileged Derivatives as Anti-Leishmanial Agents 8. Coumarin: A Privileged Scaffold for the Design and Development of Antidepressant Agents in Medicinal Chemistry 9. Coumarin Skeleton as Anti-inflammatory Agents 10. Medicinal Aspects of Coumarin Based Frameworks as Potential Antioxidant Agents 11. Current Perspectives on Coumarin Classes for Anticoagulant Therapy 12. Coumarin Derivatives: An Emerging Class of Antimutagenic Therapeutic Agents 13. Therapeutic Agents in Alzheimer's Disease: Recent Progress Based on Coumarin Core 14. Coumarin-Based Scaffold as Potential Antidiabetic Agents 15. Recent Developments of Coumarin-Containing Derivatives as Agents for Different Therapies 16. Synthesis, Characterization, and Investigation of Coumarin Based Metal Complexes 17. Therapeutic efficacy and Drug Delivery Route of Coumarin-Based Nanoparticles 18. Understanding the Coumarin Based Polymers 19. Recent Advances in Various Applications of Coumarins: Current Status and Perspectives 20. Coumarins Derivatives: A Brief Discussion on Patents

• ISBN: 978-0-443-15650-2
• Editorial: Elsevier
• Encuadernacion: Rústica
• Páginas: 400
• Fecha Publicación: 01/04/2025
• Nº Volúmenes: 1
• Idioma: Inglés