Translational Research and Discovery in Gastroenterology

INDICE: Introduction – 1 chapter Embryology overview, from gastrulation to endodermal tube and accessory organ formation, including timing of events in human vs mouse Patrick Tam, Brigid Hogan, Jim Wells Esophagus –2 chapters Development: Jianwen Que – development/including esophageal tracheal development, studies related to Barrett’s Clinical: –John Lynch – Barretts esophagus, tracheal esophageal fistula Stomach –2 chapters Development: Tae–Hee Kim (Shivdasani lab): stomach development/including mouse models of gastroschesis, volvulus Clinical: Ramesh Shivdasani or Jason Mills Pylorus –1 chapter (combined development and clinical) Development: Deb Gumucio Clinical: Brent Polk Development of the pylorus/Idiopathic Hypertrophic pyloric stenosis Small intestine –2 chapters Development: Klaus Kaestner or Nan Guo or Noah Shroyer: development, major transcriptional networks, generation of villi/absorptive surface, generation of intestinal length. Clinical: Dan Teitlebaum or Mike Helmrath Short bowel, intestinal atresias Colon 2 – chapters Development: Thad Stappenbeck or Martin J. Cohn or David Ornitz Hindgut development, anorectal malformations , caudal regression. Clinical: Yukio Saijoh (U of Utah) or Thad Stappenbeck Liver –2  chapters Development: Ben Stanger or Aaron Zorn or Ken Zaret or Steve Duncan or Fredrick P Lemaigre – include pancreas/liver/biliary choice, cholangiocyte–hepatocyte switch, chromatin considerations (pioneer factors?) Clinical– Ben Stanger or Ira J. Fox or Steve Duncan Pancreas –2 chapters Development: Doug Melton, Jim Wells, Mattias Hebrok, Charles Murtaugh, Chris Wright, Guoqiang Gu, Ray McDonald Clinical: Martin Martin, Roland Stein, Steve Leach, Rolan Schmid include type 1 diabetes, rare conditions where isets don?t develop, ngn3 mutant people, acinar diseases Serosa–1 chapter David Bader – include developmental potential of the serosa; apple peel bowel Enteric nervous system – 2 chapters Michelle Southhard Smith – development of the enteric nervous system Michael Gershon, MD – Hirshprung’s, other diseases of ENS Gut Stem Cells – 1 chapter Linda Samuelson – include major intestinal and stomach stem cells, contrast with liver and pancreas Other model organisms for the study of various aspects of gut development – up to 5 chapters Fly– Ben Ohlstein or Tony Ip Zebrafish – Didier Stainer (liver, pancreas, gut lumen), or Vicky Prince…endoderm patterning, pancreas), or Michael Pack (liver) Frog– Aaron Zorn, Chris Wylie, or Janet Heaseman Worm – Susan Mango or James McGee Sea Urchin – Dave McClay The Future – translational gut embryology – 1 chapter Jason Spence – human pluripotent stem cells to generate 2D/3D in vitro models to study human development and disease.

• ISBN: 978-1-118-49287-1
• Editorial: Wiley–Blackwell
• Encuadernacion: Cartoné
• Páginas: 392
• Fecha Publicación: 04/06/2014
• Nº Volúmenes: 1
• Idioma: Inglés