Mood and anxiety related phenotypes in mice: characterization using behavioral tests

Affecting over 15% of the world population, mood and anxiety disorders have been the subject of ever-increasing research. This increased research parallelsa remarkable growth in the use of the laboratory mouse as a tool to understand the biological and genetic basis of mood and anxiety disorders as well as todevelop improved treatments. In Mood and Anxiety Related Phenotypes in Mice: Characterization Using Behavioral Tests, world-renowned researchers provide anoverview of behavioral approaches utilized in the characterization of mood and anxiety related behaviors in mice as well as commonly used behavioral assaysto assess the potential antidepressant and anxiolytic efficacy of novel compounds. As a volume in the successful Neuromethods™ series, the chapters provideclear thought-provoking reviews including up-to-date detailed protocols of the most commonly used approaches in the field. Covers a wide range of behavioral assays used to assess the efficacy of potential novel antidepressant and anxiolytic compounds Features contributions by world-renowned scientists with broad experiences in the development and application of behavioral tasks in mice Fills the void of resources for detailed protocols specifically for the study of mood and anxiety disorders INDICE: From the contents The Open Field Test.- Analysis of Grooming Behavior and its Utility in Studying Animal Stress, Anxiety, and Depression.- Digging in Mice: Marble Burying, Burrowing, and Direct Observation Reveal Changes in Mouse Behavior.- Circadian and Light Modulation of Behavior.- Ultrasonic Vocalizations by Infant Mice: An Ethological Expression of Separation Anxiety.- The Forced Swimming Test in Mice: A Suitable Model to Study Antidepressants.- The Tail Suspension Test: A Model for Characterizing Antidepressant Activity inMice.- Stress-Induced Hyperthermia in the Mouse.- Factors of Reproducibility of Anhedonia Induction in a Chronic Stress Depression Model in Mice.- Learned Helplessness in Mice.- The Mouse Light-Dark Box Test.- Using the Elevated PlusMaze as a Bioassay to Assess the Effects of Naturally-Occurring, and Exogenously-Administered Compounds, to Influence Anxiety-Related Behaviors of Mice.- Novelty-Induced Hypophagia.

• ISBN: 978-1-60761-302-2
• Editorial: Humana
• Encuadernacion: Cartoné
• Páginas: 320
• Fecha Publicación: 01/09/2009
• Nº Volúmenes: 1
• Idioma: Inglés