Since the publication of the first edition of this book in 2010, an explosion of spectacular discoveries in the field of regeneration has compelled the current revisit of the field of Regenerative Nephrology. This second edition features subjects as diverse as age and gender influencing regenerative processes; mechanisms and pathways of premature cell senescence affecting kidney regeneration; the ways intrinsic regenerative processes can become subverted by noxious stressors eventuating in disease progression; novel mechanistic and engineering efforts to recreate functional kidney or its component parts; cell reprogramming and reconditioning as emerging tools of future regenerative efforts; and effects of various biologicals on kidney regeneration. These newer additions to the armamentarium of Regenerative Medicine and Nephrology have become an integral part of the second edition of the book. Cutting-edge investigations are summarized by the constellation of the most experienced contributing authors coming together from around the world under the umbrella of the second edition. A significant expansion of section on induced pluripotent cells and trajectories of their differentiation. This will be followed by mechanisms and modalities of cell reprogramming for therapeutic purposes A new section on tissue engineering of the kidney of interest to nephrologists and urologists An entire section dedicated to causes of regenerative failure with the emphasis on recent discoveries of senescent cells in kidney disease, pathologic effects of senescent cells, advents in senotherapies and rejuvenation therapies A vastly expanded section on pharmacotherapies promoting kidney regeneration, trials of engineered organs, manufacturing in regenerative medicine and smooth transition to the clinical trials, with an update on some ethical issues INDICE: Section 1: Kidney Development and Regeneration 1. Nephrogenesis in Health and Disease Adrian S. Woolf and Sophie L. Ashley 2. Renal organogenesis in the lymph node microenvironment Maria Giovanna Francipane 3. In vivo clonal analysis and the kidney: Implications to regenerative nephrology Oren Pleniceanu Benjamin Dekel 4. Nephrogenesis in malnutrition Brian B. Ratliff, May M. Rabadi, and Selin Celikoyar Section 2: Modulators of Regeneration 5. Endogenous anti-inflammatory and pro-resolving lipid mediators in renal disease Ross Doyle and Catherine Godson 6. T-cell in kidney injury and regeneration Li Li, Dylan Baer, and Mark D. Okusa 7. Monocytes and dendritic cells in injury and regeneration Elise N. Erman, Meryl C. Nath, Matthew D. Cheung, Anupam Agarwal, and James F. George 8. Mast cells in kidney regeneration Eric Douglas, Nicholas Charles, and Ulrich Blank Section 3: Stem Cells in Regenerative Processes 9.Regeneration and replacement of endothelial cells and renal vascular repair David P. Basile and Mervin C. Yoder 10. Stem cells in regenerative processes: Induced pluripotent stem cells Kenji Osafune 11. Nephroprotective effect of urine-derived stem cells for renal injury Yuanyuan Zhange and Anthony Atala 12. Amniotic stem cells and their exosomes Jing Ji and Li Yang 13. Regenerative potential of stem-cell-derived extracellular vesicles Hoon Young Choi and Hyeong Cheon Park 14. Stem cell therapies in diabetes Sevim Kahraman, Danielle Diegisser, and Ercument Dirice Section 4: Causes of Regenerative Failure 15. Progression of kidney disease as a maladaptive response to injury Xuezhu Li, Fend Ding, Kyung Lee, and John Cijiang He 16. Molecular mechanisms of cellular senescence Jamil Nehme, Marta Varela-Eirin, and Marco Demaria 17. Characteristics of senescent cells Roland Schmitt and Anette Melk 18. Stress-induced senescence of tubular cells David P. Baird, David A. Ferenbach, and Joseph V. Bonventre 19. Stress-induced senescence as a forme fruste of chronic kidney disease- A case for failed regeneration Michael S. Goligorsky 20. Premature vascular aging and senescence in chronic kidney disease Thomas Ebert and Peter Stenvinkel 21. Injury and regeneration in renal aging Janka Babickova, Hai-Chun Yang, and Agnes B. Fogo 22. Gender-dependent mechanisms of injury and repair Joel Neugarten and Ladan Golestaneh Section 5: Kidney Engineering 23. Glomerular stem cells Laura Lasagni, Benedetta Mazzinghi, and Paola Romagnani 24. Reconstitution of the kidney glomerular capillary wall Titilola D. Kalejaiye, Jordan A. Holmes, Rohan Bhattacharya, and Samira Musah 25. Microfluidic modeling of glomerulus and tubular appartus Gretchen J. Mahler and Stephanie Zhang 26. Matrix scaffolds in kidney engineering Sean Muir, Catherine La Pointe, Domenica Ida Marino, Amish Asthana, and Guiseppe Orlando Section 6: Emerging Clinical Aspects of Regenerative Therapy 27. Reprogramming toward kidney regeneration: New technologies and future promises Yun Xia and Juan Carlos Izpisua Belmonte 28. Therapy cell reconditioning Michael S. Goligorsky 29. Senomorphic, senolytic, and rejuvenation therapies Xiang Yang Zhu and Lilach O. Lerman 30. Natural products in regeneration Rachel B. Wilson, Jason J. Lee, Geoffrey Pickering, and Nica M. Borradaile 31. Nanotargeting to the kidney Ryan M. Williams, Chintan Kapadia, Edgar A. Jaimes, and Daniel A. Heller 32. Small molecules in regeneration Amanda E. Crunk, Aneta Przepiorski, and Neil Hukriede 33. Systems biology in diagnosis and reamtnet of kidney disease Jennifer Schaub and Matthias Kretzler 34. Overview of ethical concerns raised by kidney organoids Paola Nicolas and Ira Bedzow 35. Manufacturing challenges and solutions for tissue engineering and regenerative medicine technologies Joshua Hunsberger and Sita Somara
- ISBN: 978-0-12-823318-4
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 528
- Fecha Publicación: 16/06/2021
- Nº Volúmenes: 1
- Idioma: Inglés