This special volume of Progress in Molecular Biology and Translational Science focuses on oligomerization in health and disease. Key features: * Contributions from leading authorities * Informs and updates on all the latest developments in the field INDICE: Section I. Structural, Physico-Chemical, and Evolutionary Aspects of Protein Oligomerization Evolutionary, Physico-Chemical and Functional Mechanisms of Protein Homooligomerization Structural, Evolutionary and Assembly Principles of Protein Oligomerization Physico-Chemical Principles of Protein Aggregation Structural Aspects of Amyloid Formation Section II. Oligomerization in Seven-Transmembrane Receptors Quaternary Structure Predictions and Structural Communication Features of GPCR Dimers Challenges in the Development of Heteromer-GPCR-Based Drugs Oligomerization of GPCRs in Health and Disease on Di/Oligomerisation of GPCRS; Mechanisms and Functional Significance G Protein-Coupled Receptor Heterocomplexes in Neuropsychiatric Disorders Disease-Specific Heteromerization of G Protein-Coupled Receptors that Target Drugs of Abuse Section III. Oligomerization in Ion Channels Social Networking among Voltage-Gated Potassium Channels Oligomerization of the Mitochondrial Protein VDAC1: From Structure to Function and Cancer Therapy Consequences of Dimerization of the Voltage Gated Proton Channel Receptor Heteromeric Assembly, How it Works and Why it Matters - The Case of Ionotropic Glutamate Receptors Section IV. Oligomerization in Enzymes The Structural Basis for the Allosteric Regulation of Ribonucleotide Reductase Oligomerization of Dynamin Superfamily Proteins in Health and Disease Multimerization of the Dnmt3a DNA Methyltransferase and its Functional Implications Oligomerization in Endoplasmic Reticulum Stress Signaling Section V. Oligomerization in Regulatory Proteins Toll-IL-1-Receptor-Containing Adaptor Molecule-1 (TICAM-1), a Signaling Adaptor Linking Innate Immunity to Adaptive Immunity Assembly of Gamma-Tubulin Ring Complexes: Implications for Cell Biology and Disease Chemokine Oligomerization in Cell Signaling and Migration Oligomerization of Rab/Effector Complexes in the Regulation of Vesicle Trafficking
- ISBN: 978-0-12-386931-9
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 656
- Fecha Publicación: 03/07/2013
- Nº Volúmenes: 1
- Idioma: Inglés