Mesenchymal Stromal Cells as Tumor Stromal Modulators

Mesenchymal Stromal Cells as Tumor Stromal Modulators provides the latest data on the heterogeneous cell population, reporting on topics such as immunomodulating, tissue repairing, differentiating, and their migratory and angiogenic abilities that make them important tools for clinical and translational research. An understanding of the role of MSCs in modulating tumor growth provides a glimpse into their role in non-pathological tissue remodeling and potential regenerative tissue therapies. The book is a comprehensive source for the n understanding of the role of MSCs as ubiquitous connective tissue cell components which may have both direct and indirect effects on the tumor microenvironment and potential for regenerative therapeutics for various diseases. Using cancer as a model disease, this book explores the transformative role MSCs play in the recruitment of disease cells, cell repair, and immunological defenses. Explores the biology of Mesenchymal Stromal Cells (MSCs) and tissue related functionDiscusses the bidirectional communication between tumor stroma and MSCs derived from bone marrow, adipose tissue, and other tissue typesProvides in-depth analysis of the effects of MSCs on key processes that regulate disease progression, such as angiogenesis, metastatic potential, invasion, proliferation, and tumor immune privileges INDICE: I. Introduction -Origin and discovery of Mesenchymal Stromal Cells (MSCs); tissue related function. Biological properties and hierarchy; relationship with fibroblasts. Differentiation potential and relationship with the biological niche. -MSCs and tissue location. Sources for MSCs. MSCs from adipose tissue. MSCs from bone marrow. MSCs from other adult tissue locations. MSCs from neonatal tissues. II. Crosstalk between the MSCs and tumor -Tumor MSCs recruitment. -Tumor stroma formation and MSCs. -MSCs effect on tumor microenvironment. -MSCs and the immune system. III. Potential use of MSCs connective tissue therapies -MSCs as cellular carriers. Adenovirus delivery. Expression of suicide genes. Oncolytic viruses. Nanoparticles and MSCs targeting.  -MSCs' microvesicles IV. Final Remarks and discussion. MSCs as cellular tissue repositories. Potential new therapeutics

• ISBN: 978-0-12-803102-5
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 552
• Fecha Publicación: 01/03/2016
• Nº Volúmenes: 1
• Idioma: Inglés