Neurobiology of actin: from neurulation to synaptic function

This text is an introduction to the interface between the actin cytoskeleton and the myriad of issues fundamental to the understanding of the nervous system. It covers the neurobiology of actin ranging from basic cellular organization and function to the roles of actin in the health and disease states of the nervous system. Its opening chapter presents the fundamental concepts required to appreciate the details of the molecular machinery that regulates actin in acellular context, setting the stage for the first part of the book which reviews the neurobiology of actin at the cellular level. The latter section of thebook then discusses the functions of actin in the context of neurobiological issues ranging from early development to synaptic function and disease states of the nervous system. This text is intended for neuroscientists interested ininvestigating the actin cytoskeleton in the context of their particular neuroscience research program, and its chapters are cross-referenced in order to assist readers in finding relevant information that is covered in greater depth in other chapters. 1. Introduces key issues linking the actin cytoskeleton to the nervous system 2. Chapters are written by expert researchers and cover a wide variety of topics, starting with the process of neurulation and culminating with the regulation of synaptic function 3. Presents topics in the context of clinically relevant issues related to the neurobiology of actin and disease states of the nervous system INDICE: Introduction to the Neurobiology of Actin.- The Neuronal Actin Cytoskeleton and the Protrusion of Lamellipodia and Filopodia.- Regulation of Actin Filaments During Neurite Extension and Guidance.- Functions of Myosin MotorProteins in the Nervous System.- Microtubule-Actin Interactions During Neuronal Development.- Working with Actin: Methodological Approaches for the Study of Actin in Neurons.- Functions of the Actin Cytoskeleton in the Early Embryology of the Nervous System.- Actin Cytoskeletal Regulation in Neuronal Migration.- Actin and Neuronal Polarity.- Actin at the Synapse: Contribution to Pre andPost-synaptic Functions.- Actin and Diseases of the Nervous System.- Signal Transduction Pathways: From Receptor to the Actin Cytoskeleton.

• ISBN: 978-1-4419-7367-2
• Editorial: Springer
• Encuadernacion: Cartoné
• Páginas: 350
• Fecha Publicación: 29/11/2010
• Nº Volúmenes: 1
• Idioma: Inglés