Oxidative stress and free radical damage in neurology

This book will examine the role of oxidative stress in neurological disorders. The role of free radicals and antioxidants, referred to collectively as 'oxidative stress,' is receiving constant attention in relation to disease processes. As of October 2007, a search on PubMed indicates there are 6661 reports linked with oxidative stress in the CNS and 534 reports in the PNS. The number for psychosocial behavior is 1113. These articles are primarily concerned with the use of predictive biomarkers and the effect of multiple antioxidants administered for therapeutic intervention on neuropathology. There is increasing evidence that oxidative stress is a causative, or at least a supportive factor, in several neurological diseases. Oxidative stress also plays a regulatory role in transcription, signal transduction, gene expression, mitochondrial function, membrane trafficking and postsynthetic damage. INDICE: Why is the nervous tissue vulnerable to oxidative stress.- The role of free radicals in the nervous system.- Neuronal oxidative stress and heavymetals.- Antioxidant enzymes mimics and metal co-factors.- The potential roleof glutamate in neurodegeneration.- The potential role of homocysteine in neurodegeneration.- The possible role of free radicals in bacterial and viral infection of the CNS.- Free radical damage in traumatic brain injury.- Free radicals and brain edema.- The role of free radicals in inborn errors of metabolism.- Free radicals in neurodegenerative diseases of the aged.- The role of free radical damage in stroke.- Oxidative stress and myelin.- Oxidative stress in multiple sclerosis.- Oxidative stress and epilepsy.- Oxidative stress and deafness.- Redox and neurotoxins (Lathyrism).- The therapeutic value of antioxidants and radical scavengers in neurological disorders.- Nanopharmacology and drugdelivery.

• ISBN: 978-1-60327-513-2
• Editorial: Humana
• Encuadernacion: Cartoné
• Páginas: 400
• Fecha Publicación: 01/06/2010
• Nº Volúmenes: 1
• Idioma: Inglés