Hit and lead profiling: identification and optimization of drug-like molecules

Following a brief introduction to the necessities of filtering and risk assessment of potential new drug molecules before the actual drug development, the two equally important aspects of pharmacological (ADME) and safety (Toxicity) profiling are covered in separate parts in this modern practical reference. The ADME part covers the profiling of basic physicochemical parameters, such as solubility and permeability, but also more complex traits such as the likelihood of drug-drug interactions, metabolic clearance and protein binding properties. The Toxicology part addresses, among others, recent advances in early genetic toxicity testing, bioactivation screening, organ-specific toxicity assays for liver, heart, kidney and blood, as well as profiling for autoimmune reactions. In summary, here is the complete toolbox to assess the risk/benefit ratiofor any novel compound during the early drug development stages, using both in vitro and in silico methods. Invaluable know-how for every medicinal chemistand drug developer.

• ISBN: 978-3-527-32331-9
• Editorial: Wiley-VCH
• Encuadernacion: Cartoné
• Páginas: 480
• Fecha Publicación: 19/08/2009
• Nº Volúmenes: 1
• Idioma: Inglés