This volume in the Handbook of Clinical Neurology (Series Editors: Michael J.Aminoff, Department of Neurology, University of California, San Francisco, USA; François Boller, Bethesda, USA; Dick F. Swaab, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands) deals with neuropathology, physiopathology, biology, clinics, and imaging of all or most dementing disorders that are presently known. It also includes chapters on the legal and ethical issues to give the health care worker a general view on diseases that are not only scientific riddles, but also the cause of affliction of many patients and of their families. Recently several major new advances in understanding have been made and are covereed in this volume (for example the progranulin mutation and the role of TDP-43). All those dealing with dementia, at whatever level of expertise, may find this volume of value.. INDICE: Section 1: General aspects:History of dementia. Neuropsychologicalexamination in dementia. Executive dysfunction and neuropsychological testing. Neuropsychiatric evaluation in dementia. Electrophysiological evaluation of dementia. Feature extraction and strategy of analyzing structural neuroimagingin dementia. Strategies for using molecular neuroimaging in dementia. Qualityof life in dementias. Diagnosis and management of caregiver burden in dementia. The memory disorders clinic. Legal aspects of dementia. Ethical issues in the care of the patient with dementia. Economical aspects of dementia. Neuropathologic classification of dementias: introduction. Tau, a biological marker ofneurodegenerative diseases. Biologic models of neurodegenerative disorders. The relationship between nosology, etiology and pathogenesis in neurodegenerative diseases. Section 2: Specific disorders:Alzheimer's disease:Alzheimer's disease: epidemiology. Clinical symptoms in Alzheimer's disease. Mild cognitive impairment. The genetics of Alzheimer's disease. Neuropathology of Alzheimer's disease. Biochemistry and molecular biology of amyloid -protein and the mechanism of Alzheimer's disease. Biological CSF Markers of Alzheimerías disease. Symptomatic therapeutic aspects in Alzheimer's disease. Perspectives of Alzheimer's disease treatments. Biological transgenic mouse models of Alzheimer's disease. Lewy body diseases:Clinical aspects of Parkinson dementia. Clinical aspects of dementia with Lewy bodies. The genetics and molecular biology of alpha-synuclein. Neuropathology of dementia with Lewy bodies.Frontotemporal dementias: Epidemiological aspects of frontotemporal dementia. Frontemporal lobar degeneration: clinical and pathologic overview. Clinical aspects of hereditary frontotemporal dementia. Clinical aspects of TDP-43 proteinopathy, neurofilament inclusion body disease and dementias lacking distinctive proteinopathy. The genetics of frontotemporal dementia. Neuropathology of hereditary forms of frontotemporal dementia and parkinsonismNeuropathology of Pick body disease. Dementia and motor neuron disease. Neuronal intermediate filament inclusion disease. Biological models in frontotemporal dementias.Progressive supranuclear palsy :The epidemiology of progressive supranuclear palsy. Clinical aspects of progressive supranuclear palsy. Genetics of progressive supranuclear palsy. Neuropathology of progressive supranuclear palsy. Current and future therapeutic approaches in progressive supranuclear palsy.Corticobasal degeneration:Corticobasaldegeneration: clinical aspects. Neuropathology and genetics of corticobasal degeneration. Current and future management of the corticobasal syndrome and corticobasal degeneration.Agyrophilic grainsClinical aspects of dementia with argyrophilic grains. Argyrophilic grain disease.Hippocampal sclerosis:Clinical aspects of hippocampal sclerosis. Neuropathology of hippocampal sclerosis.Primary progressive aphasias:Primary progressive aphasia and kindred disorders.Huntingtonías disease:Pre-symptomatic Huntington's disease. Neuropathology of Huntington's disease. The biology of Huntington's disease. Therapeutic approach inHuntington's disease.Vascular dementias:The epidemiology of vascular dementia. Clinical and therapeutic aspects of vascular dementia. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy . The neuropathology of vascular and mixed dementia and vascular cognitive impairment.Demyelinating disorders:Understanding and managing cognitive dysfunction in multiple sclerosis. Neuropathology of cognitive dysfunction in multiple sclerosis. Leukodystrophies: clinical and therapeutic aspects.Transmissable diseasesClinical and therapeutic aspects of prion disease. Clinical aspects of variant Creutzfeldt-Jakob disease. Biology and neuropathology of prion diseases. Humanimmunodeficiency virus-associated dementia: clinical aspects, biology, and treatment. Neuropathology and HIV dementia. Clinical and therapeutic aspects of dementia in syphilis and Lyme disease. Biology and neuropathology of dementia in syphilis and Lyme disease.Toxic diseases:Epidemiology of alcohol-related dementia. Toxic dementias. Neuropathology of alcohol-related cognitive alterations.Cancer:Paraneoplastic disorders of the memory and cognition: clinical aspects and therapeutic approaches. Brain tumors and dementia.Hydrocephalus:Clinical aspects and biology of normal pressure hydrocephalus.
- ISBN: 978-0-444-51898-9
- Editorial: Elsevier Science
- Encuadernacion: Cartoné
- Páginas: 936
- Fecha Publicación: 09/06/2008
- Nº Volúmenes: 1
- Idioma: Inglés