Functional Neural Transplantation IV: Translation to Clinical Application, Part B

Functional Neural Transplantation IV: Translation to Clinical Application, Volume 231 provides a survey of the current status of cell transplantation in the nervous system, with a focus on the conditions for achieving structural repair and functional recovery after brain damage or in neurodegenerative disease. As the fourth in a periodic series of updates at 5-7 year intervals, this volume highlights recent developments related to the application of advances in cellular and molecular science to an understanding of the fundamental principles of neuroplasticity and regeneration in the brain and spinal cord, also addressing the topic of the power of pluripotent stem cells to generate new sources of precisely specified neurons for utilization in brain repair. Selected chapters review the latest advances in translating the new technologies to a broader range of neurodegenerative diseases, stroke, spinal cord injury, glial and retinal disease and pain than had hitherto been considered possible, with the realization that the opportunities of off-the-shelf cell therapy may fast be approaching a plausible reality. Comprehensive set of critical reviews covering the fieldPresents state-of-the-art topics in science and translational medicineWritten by international leaders in the field of neural transplantation INDICE: 1. Stem cell transplantation for spinal cord repairP. Lu 2. Plasticity and regeneration in the injured spinal cord after cell transplantation therapyS. Nori, M. Nakamura & H. Okano3. Transplantation of GABAergic interneurons for cell-based therapyJ. Spatazza, W.R. Mancia Leon & Arturo Alvarez-Buylla4. Rebuilding inhibitory CNS circuits to control chronic neuropathic pain and itchJ. Braz, A. Etlin, D. Juarez-Salinas, I.J. Llewellyn-Smith & A. Basbaum5. From transplanting Schwann cells in experimental rat spinal cord injury to their transplantation into human injured spinal cord in clinical trialsM.B. Bunge, P. Monje, A. Khan & P.M. Wood 6. Recruiting endogenous CNS stem cells for regeneration in demyelinating diseaseN.A. Murphy & R.J. M. Franklin7. Glial progenitor transplantation and repairS.A. Goldman8. Stem-cell derived photoreceptor transplantation in the retinaN. Aghaizu, K. Fruczek, A. Gonzalez-Cordero, R.R. Ali & R.A. Pearson9. RPE transplantation for treatment of retinal diseaseP.J. Coffey10. Transplantation of reprogrammed neurons for improved recovery after strokeZ. Kokaia, D. Tornero & O. Lindvall

• ISBN: 978-0-12-813879-3
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 470
• Fecha Publicación: 01/06/2017
• Nº Volúmenes: 1
• Idioma: Inglés