Mechanisms of Morphogenesis, Third Edition offers a bottom-up discussion of mechanisms of cell and tissue morphogenesis in a diverse array of organisms, including prokaryotes, animals, plants and fungi. Across foundational, applied and methods-based chapters, this book examines molecular nano-machines cooperation, generate cell shape, direct cell migration, and shape, form and rates of growth of various tissues in the body. Each topic is illustrated with experimental data from real systems, with particular reference to gaps in current knowledge and likely future developments, along with strategies to apply basic morphogenesis science across ever evolving applications. Newly added chapters feature case-study-driven discussions of morphogenesis in natural embryos and organoids, and illustrate how pathological morphogenesis can generate variants of body form. This edition has also been updated with analysis of large-scale and scale-invariant mechanisms, for example, morphogenesis by differential growth in mechanically connected tissues. Includes over 200 full color figures and charts Offers an integrated view of theoretical developmental biology and computer modeling with laboratory-based discoveries Includes applied, case-study-driven discussion of experimental techniques Is organized around principles and mechanisms, using them to integrate discoveries from a range of organisms and systems across new applications Covers recent developments in morphogenesis research, including morphogenesis in organoids, other engineered tissues, and an analysis of large-scale and scale-invariant mechanisms INDICE: Section I: Introduction 1. General introduction - the aims and structure of this book. 2. Key principles of morphogenesis 3. The power and limitations of self-assembly Section II: Cell shape and the cell morphogenesis 4. Morphogenesis of individual cells 5. Animal cell shape: the importance of the cytoskeleton 6. Cellular morphogenesis in plants Section III: Cell Migration 7. Cell migration in development: a brief overview 8. The nanomachinery of locomotion 9. Guidance by chemotaxis 10. Guidance by galvanotaxis 11. Guidance by contact 12. Waypoint navigation in the embryo 13. Cooperative migration of mesenchymal cells 14. Condensation of cells Section IV: Epithelial Morphogenesis 15. The epithelial state: a brief overview 16. Neighbour exchange and convergent extension 17. Closure of holes 18. Invagination and evagination 19. Epithelial fusion 20. Epithelial branching 21. Boundaries to epithelial movement Section V: Morphogenesis by cell proliferation and death 22. Growth, proliferation and death: a brief overview 23. Morphogenesis by orientated cell division 24. Morphogenesis by elective cell death Section VI: Morphogenesis in context 25. From mechanisms to morphology: a brief overview 26. Morphogenesis in embryos: some illustrative examples 27. Morphogenesis in organoids, embryoids and engineered tissues 28. Pathological morphogenesis Section VII: Modelling morphogenesis 29. Modelling morphogenesis: a brief overview 30. Mechanical and mathematical models of morphogenesis 31. Modelling using living cells - tissue engineering and synthetic morphology Section VIII: Conclusion and perspectives 32. Conclusion and perspectives
- ISBN: 978-0-323-99965-6
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 532
- Fecha Publicación: 14/06/2023
- Nº Volúmenes: 1
- Idioma: Inglés