Osmolytes and Intrinsically Disordered Proteins: From functional regulation to disease pathogenesis

Osmolytes and Intrinsically Disordered Proteins: From Functional Regulation to Disease Pathogenesis delves into the fascinating interplay between osmolytes and intrinsically disordered proteins (IDPs), exploring their pivotal roles in cellular function and disease mechanisms. This comprehensive volume brings together leading experts to present cutting-edge research on how osmolytes regulate functional behavior of IDPs and ensure cellular stability and adaptability under stress conditions. The book also examines the implications of these interactions in various diseases, offering insights into potential therapeutic approaches. Through a blend of theoretical perspectives and experimental findings, this edited collection represents an essential resource for better understanding of the dynamic nature of IDPs and their critical impact on health and disease. Comprehensive Coverage: The volume offers an in-depth exploration of the relationship between osmolytes and intrinsically disordered proteins (IDPs), spanning from basic functional regulation to the roles in the pathogenesis of various diseaseExpert Contributions: Featuring chapters written by leading researchers and experts in the field, the book provides the latest findings on osmolyte-IDP interactions in molecular levels and implications in important biological processesTherapeutic Insights: The volume not only elucidates the fundamental science behind IDPs and osmolytes but also highlights potential therapeutic approaches, making it a valuable resource for both researchers and clinicians aiming to develop new treatments for related diseases INDICE: 1. Functional diversity of IDPs and their structural heterogeneity: Protein structure-function continuumVladimir N. Uversky2. Osmolytes as structure-function regulators of intrinsically disordered caseinMohd. Younus Bhat3. Synergism of the effects of osmolytes and crowders on structure and function of IDPs/IDRs: The natural habitatTerrence G. Oas4. Osmolyte-IDP Interactions during DesiccationVincent Nicholson, Thomas Boothby and Emma K. Meese5. Modulation of aggregation/fibrillation propensity of IDPs by osmolytesTanveer Ali Dar Sr.6. Osmolytes in modulating the structural and functional integrity of a-synuclein: a study based on Parkinson's diseaseLaishram R. Singh7. Regulation of the structural dynamics, aggregation, and pathogenicity of polyQ-expanded Huntingtin by osmolytes.Alice Y. Liu, Amala Mathew, Christopher Karim, Pierre Eshak and Kuang Yu Chen8. Md Nadir Hassan, Murtaza Hussain, Rizwan Hasan Khan, Aggregation and inhibitory strategies of amyloid fibrillationRizwan Hasan Khan and Rizwan H. Khan9. Modulation of amyloid beta and Tau aggregation by Phytochemicals: Implications in Alzheimer’s DiseaseMohd. Kamil Hussain, Shakir Ahamad, Moazzam Ahmad, Mohammad Saquib, Shahnaaz Khatoon, Karam Fatima and Mohsin Vahid Khan10. The Emerging Landscape of Natural Small-molecule Therapeutics for Huntington’s DiseaseShahnawaz Ali Bhat, Shakir Ahamad, Sameera Khan and Nargis Bano11. Molecular crowding and amyloidogenic self-assembly: emergent perspectives from modern computationsNeelanjana Sengupta

• ISBN: 978-0-443-29320-7
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 300
• Fecha Publicación: 01/02/2025
• Nº Volúmenes: 1
• Idioma: Inglés