The Use of Mass Spectrometry Technology (MALDI-TOF) in Clinical Microbiology

The Use of Mass Spectrometry Technology (MALDI-TOF) in Clinical Microbiology presents the state-of the-art for MALDI-TOF mass spectrometry. It is a key reference defining how MALDI-TOF mass spectrometry is used in clinical settings as a diagnostic tool of microbial identification and characterization that is based on the detection of a mass of molecules. The book provides updated applications of MALDI-TOF techniques in clinical microbiology, presenting the latest information available on a technology that is now used for rapid microbial identification at relatively low cost, thus offering an alternative to conventional laboratory diagnosis and proteomic identification systems. Although the main use of the technology has, until now, been identification or typing of bacteria from a positive culture, applications in the field of virology, mycology, microbacteriology and resistances are opening up new opportunities. Presents updated applications of MALDI-TOF techniques in clinical microbiologyDescribes the use of mass spectrometry in the lab, the principles of the technology, preparation of samples, device calibration and maintenance, treatment of microorganisms, and quality controlPresents key information for researchers, including possible uses of the technology, differences between devices, how to interpret results, and future applicationsCovers the topic in a systematic and comprehensive manner that is useful to both clinicians and researchers INDICE: 1. Proteomics: technology and applications2. Basis on mass spectrometry. Technical variants3. MALDI-TOF commercial platforms for microbial identification4. Work procedures in MALDI-TOF technology5. Indications, interpretation of results, advantages, disadvantages and limitations of MALDI-TOF6. Quality control in MALDI-TOF techniques7. Application of MALDI-TOF for bacterial identification8. Detection of bacterial resistance through MALDI-TOF technology9. Direct identification of pathogens from positive blood cultures by MALDI-TOF technology10. Use of MALDI-TOF techniques in the diagnosis of urinary tract pathogens11. Direct application of MALDI-TOF mass spectrometry to cerebrospinal fluid for pathogen identification12. Application of MALDI-TOF in clinical virology13. Use of MALDI-TOF mass spectrometry in microbacterial diagnosis14. Use of MALDI-TOF mass spectrometry in fungal diagnosis15. Application of MALDI-TOF in bacterial strain typing and taxonomy16. Future applications of MALDI-TOF mass spectrometry in clinical microbiology

• ISBN: 978-0-12-814451-0
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 252
• Fecha Publicación: 01/08/2018
• Nº Volúmenes: 1
• Idioma: Inglés