Pathophysiological Aspects of Proteases in Cancer

Pathophysiological Aspects of Proteases in Cancer provides a comprehensive overview of the multifaceted field of proteases in the cellular environment and focuses on the recently elucidated functions of complex proteolytic systems in physiology and pathophysiology. In 25 chapters this book both gives insight in the general aspects of the role of proteases in cancer, their role as diagnostics and prognostics biomarkers, their impact on chemoresistance and the future cutting edge technologies like cocktail therapies and Cyber Knief technology. Given the breadth and depth of information covered in the respective contributions, the book will be immensely useful for researchers in oncology and working to identify targets for drug development. Multidisciplinary in scope, the book bridges the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry, making it a thought-provoking read for basic and applied scientists engaged in biomedical research. Gives insight into the spectrum of proteases, protease inhibitors, and protease interactors involved at the cellular and molecular level in cancer developmentGives a comprehensive overview of the role of proteases in modulating cellular metabolism and chemoresistance to better understand how proteases play in early to the end point in cancer development and metastasisProvides a multidisciplinary approach demonstrating the biochemical and signal transduction mechanisms associated with dysregulation of proteases, leading to the manifestation of various diseasesHighlights the roles and regulation of different types of proteases, as well as their synthetic and endogenous inhibitorsBridges the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry INDICE: A. General Aspects1.Pathophysiological aspects of calpains in cancer2. Extracellular proteases in glioblastoma3. Understanding the role of mitochondrial proteases in cancer development and progression4. Radiation injury and proteases in cancer5. Insights into the potential significance of cysteine proteinase in lung cancer6. Glycocalyx proteases in cancer metastasis7. Proteases in Head and Neck Cancer8. Dual role of the ADAMTS family in breast cancer9. Role of metallo-proteases in colon cancer proliferation and metastases10. Matrix metalloprotease and uveal melanomanasesB. Proteases as diagnostics and prognostics biomarkers11. Protease activator receptor-1 and Matrix Metalloproteinase-1 as prognostic factors and a novel therapeutic targets for gastric cancer12. Calpains as diagnostic and prognostic biomarkers of cancer13. Cathepsins as a diagnostic and prognostic marker in Oral Cancer14. Urokinase-plasminogen activator system as diagnostic and prognostic markers of cancer15. Serine proteases as biomarkers in wound healing of lung cancer16. The role of acetylcholinesterase in cancer development and possible therapeutic applications.C. Cutting Edge Technologies17. Future vision of protein inhibitors in context of cocktail and singular therapy18. Different ways of identification and characterization of proteases in cancer19. CyberKnief technology and cancer management D. Protease, chemoresistance and cancer20. Serine proteases, chemoresistance and cancer21. Cathepsins, chemoresistance and cancers22. Matrix metalloproteinases, chemoresistance and cancer23. MMPs(-2 and -9) mediated drug resistance and their reversal in gynecological cancer24. Unraveling the potential of HtrA serine proteases in anti-cancer strategies25.The link between trypsinogen and chymotrypsinogen in gastrointestinal cancer

• ISBN: 978-0-443-30098-1
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 500
• Fecha Publicación: 01/11/2024
• Nº Volúmenes: 1
• Idioma: Inglés