These new volumes of Methods in Enzymology (554 and 555) on Hydrogen Sulfide Signaling continue the legacy established by previous volumes on another gasotransmitter, nitric oxide (Methods in Enzymology volumes 359, 396, 440, and 441), with quality chapters authored by leaders in the field of hydrogen sulfide research. These volumes of Methods in Enzymology were designed as a compendium for hydrogen sulfide detection methods, the pharmacological activity of hydrogen sulfide donors, the redox biochemistry of hydrogen sulfide and its metabolism in mammalian tissues, the mechanisms inherent in hydrogen sulfide cell signaling and transcriptional pathways, and cell signaling in specific systems, such as cardiovascular and nervous system as well as its function in inflammatory responses. Two chapters are also devoted to hydrogen sulfide in plants and a newcomer, molecular hydrogen, its function as a novel antioxidant. Continues the legacy of this premier serial with quality chapters on hydrogen sulfide research authored by leaders in the field Covers conventional and new hydrogen sulfide detection methodsCovers the pharmacological activity of hydrogen sulfide donorsContains chapters on important topics on hydrogen sulfide modulation of cell signaling and transcriptional pathways, and the the role of hydrogen sulfide in the cardiovascular and nervous systems and in inflammation INDICE: HYDROGEN SULFIDE DETECTION METHODS1. Solution chemistry of H2S and its implications for biological samples Peter Nagy2. Measurement of H2S in vivo and in vitro by the monobromobimane method Christopher G. Kevil3. Fluorescent probes based on nucleophilic substitution-cyclization of H2S detection and bioimaging Ming Xian4. Fluorescent probes for the detection of H2S: reduction of azides, bi-nucleophilic reactions, coordination of Cu2+, reversible nucleophilic addition Christopher Chang5. Chemiluminescent methods for H2S detection Michael D. Pluth6. Quantification of hydrogen sulfide concentration using methylene blue and 5,5'-dithiobis(2-nitrobenzoic acid) Zhong-Guang Li7. H2S detection by sulfur chemiluminescence coupled to gas chromatography Ruma BanerjeeHYDROGEN SULFIDE DONORS AND THEIR PHARMACOLOGICAL ACTIVITY8. Synthesis and evaluation of phosphorodithioate-based H2S donors Ming Xian9. The biological effects of GYY4137 -a slow releasing H2S donor Philip K. Moore and P Rose 10. Hydrogen sulfide-releasing L-Dopa synthesis Jinsong BianHYDROGEN SULFIDE METABOLISM IN MAMMALIAN TISSUES11. Enzymology of H2S biogenesis and catabolism Ruma Banerjee12. Oxidation of H2S in mammalian cells and mitochondria Frédéric Bouillaud13. Redox regulation of mammalian 3-mercaptypyruvate sulfurtransferase Noriyuki Nagahara14. Role of human sulfide:quinone oxidoreductase in H2S metabolism Marilyn Schuman Jorns15. H2S regulation of nitric oxide metabolism Christopher G. Kevil
- ISBN: 978-0-12-801512-4
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 412
- Fecha Publicación: 01/03/2015
- Nº Volúmenes: 1
- Idioma: Inglés