Nerve Repair is a historically-based, translational review of the clinical and basic science relevant to nerve repair and regeneration. It summarizes pertinent research for the clinician, and the clinical aspects of nerve repair forthe scientist. The central themes are the axonal disorganization inherent in regeneration, the functional consequences of this disorganization, and the mechanisms used to compensate for it. Peripheral nerves are biologic wires that convey the desire for motion from brain to muscle, and the experience of touch from skin to brain. When a nerve is cut, the individual fibers, or axons, mustregenerate from the site of injury to reconnect with their skin and muscle targets. Nerve regeneration is a process of bewildering complexity that requiresthe coordinated action of multiple biologic systems. Gene expression within the neuron is altered to support axon growth,regenerating axons must cross the complex environment of the nerve injury andenter pathways that lead to functionally appropriate end organs, Wallerian degeneration clears these pathways of axon debris, and Schwann cells in the distal nerve must produce growth factors to support regeneration. In spite ofthis complexity, the surgical repair of transected nerve remains a mechanicalprocess that has changed little in the last century, and that restores normalfunction to only 10% of adults with nerve injuries.Improving the outcome of nerve repair will require close cooperation between surgeon and scientist. Skyrocketing clinical demands on the surgeon and the rapidly increasing sophistication of neuroscience have interacted to form two distinct cultures. Nerve Repair bridges these cultures by providing a translational review of the clinical and basic science relevant to nerve repair. It provides the clinician with an understanding of pertinent research, and the basic scientist with anoverview of the clinical manifestations of nerve injury and regeneration. It is also grounded in the history of peripheral nerve surgery and biology so that modern concepts can be understood in the context of their origins.
- ISBN: 978-0-19-516990-4
- Editorial: Oxford University
- Encuadernacion: Cartoné
- Páginas: 480
- Fecha Publicación: 23/06/2011
- Nº Volúmenes: 1
- Idioma: Inglés