Nitric Oxide as a Chemosensitizing Agent is the first of its kind to describe several reviews by authoritative scientists and clinicians and novel findings of the reversal of drug resistant cancers by the combination treatment of Nitric Oxide and sub toxic concentrations of chemotherapeutic drugs, reported in both in vitro and in preclinical models in vivo and in few reports in cancer patients. The book also describes the various underlying chemical, molecular, and genetic mechanisms by which NO and NO reactive species mediate the anti-cancer activity and reducing the threshold of drug resistance, thus enabling chemo therapeutic drugs to induce their cytotoxic activity and reversal of resistance. This book exposes scientists and clinicians to this new potential therapeutic field that is highly beneficial for research investigations and the pharmaceutical companies to implement further research in their RX&D. The positive pre-clinical studies reported lately and early clinical trials demonstrate the potential therapeutic application of the combination in the reversal of drug resistance in patients. The book is a valuable resource for cancer researchers, oncologists and members of several areas of biomedical field who are interested in understanding in depth how to use Nitric Oxide as a sensitizing agent for chemotherapy. Brings updated information reviewed by experts in the fieldPresents experts analysis and summary of reported and novel findings and potential translational application in cancer patientsDescribes molecular mechanisms with new and helpful approaches for the readers to use them in their own investigations INDICE: 1. Clinical studies of the combination of GTN and chemotherapy in NSCLC 2. Nitric oxide and drug releasing nanospheres in chemo-resistance 3. Inducible nitric oxide synthase and resistance to chemotherapy 4. Molecular mechanism of NO-mediated chemo-sensitization via modulation of the NF-kappaB/YY1 /SNAIL/ RKIP loop 5. NO-mediated S-nitrosylation and regulation of chemo-resistance 6. Role of NO induction in macrophages and chemo-resistance 7. Macro-molecular NO releasing scaffolds and chemo-resistance 8. NO-mediated inhibition of the chemo resistant factor Yin Yang-1 (YY1) 9. Cell signaling mediated by iNOS/NO in chemo-resistance 10. NO-mediated regulation of invasion and metastasis in chemo-resistant cancers 11. Role of NO-induced chemo-sensitization via inhibition of HIF-1 alpha 12. Clinical effect of GTN in combination with chemotherapy in coro/rectal cancers 13. Deciphering the biological Interaction of Nitric Oxide in cancer therapy 14. Role of NO induced S-nitrosylation in reversal of resistance 15. Role of NO-H2S donors in chemo-sensitization of resistant cancers 16. The NO donor JS-K sensitizes tumor cells to chemotherapy 17. Reversal of drug-resistant breast cancer by S-nitrosylation 18. Induction of NO by iNOS gene therapy and chemo resistance 19. Sensitization to chemotherapy by gene therapy-induced NOS-3 20. NO-mediated peroxynitrite formation and reversal of chemo-resistance 21. Sensitization of tumor cell to death ligands by GTN 22. Role of NO-induced inhibition of hyboxia and chemo-resistance 23. Effect of NO dosages in the regulation of chemo-resistance 24. Sensitization of cancer cells by NO donors in combination with photodynamic therapies 25. NO-mediated S-nitrosylation and regulation of metastasis in chemo-resistant cancer 26. Preclinical and clinical effects of RRX-001 in combination with chemotherapy 27. Efficacy of NO in chemo-resistant ovarian cancer 28. Clinical effects of GTN patches in combination with chemotherapy in prostate cancer 29. NO regulation of suppressive factors and chemo-resistance 30. Efficacy of the NO donor, JS-K, in chemo-resistant glioma 31. Sensitization of malignant glioma by the NO donor PABA/NO to chemotherapy
- ISBN: 978-0-12-811020-1
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 300
- Fecha Publicación: 01/06/2017
- Nº Volúmenes: 1
- Idioma: Inglés