Translational Advances in Gynecologic Cancers straddles the bench and bed divide by highlighting important and interesting research that is translatable to the clinic. The contents of this book cover the entire spectrum, from promising laboratory based research, to clinical trial efforts. Further, new therapeutic indications based upon randomized phase III trials are also included. Clinicians will learn about lab-based science that is about to enter the clinic, along with the rationale behind translational endpoints in trials. Researchers will be able to identify and understand the clinical needs of patients with these types of tumors to improve their research focus. Provides a comprehensive description of all evolving translational gynecologic cancer research for cliniciansIdentifies knowledge gaps to inform the next research directionTies together clinical research and patient needs to help both the researcher and clinicianAddresses genomics, new target therapies, novel tools, and more for ovarian, endometrial, and cervical cancer INDICE: Section I: OVARIAN CANCER 1. Origins of ovarian cancer: implications in therapy 2. Ovarian cancer genomics / Gene signature sensitivity to target therapy 3. Epigenetics 4. Role of Primary vs Interval Debulking Surgery 5. Angiogenesis 6. Homologus Recombination Repair and BRCA 7. PARPi and associations 8. New targets (Folic Acid target therapy, FGF pathway, KRAS / BRAF pathway, TGF pathway, PI3K /AKT pathway, Immunotherapy, virotherapy?); 9. Novel chemotherapy tools (IP therapy, Dose dense therapy) 10. Grade/histology specific therapy (high grade serous /endometrioid OC; low grade serous ovarian cancer; clear cell OC; mucinous OC) Section II: ENDOMETRIAL CANCER 11. Endometrial cancer genomics 12. Minimal invasive surgery - Lymphadenectomy and nodes dissection (LNS) in endometrial cancer 13. New target therapies in endometrial cancer 14. Radiotherapy in endometrial cancer (IMRT, IORT, proton beam) Section III: CERVICAL CANCER 15. Cervical cancer genomics 16. New therapies in cervical cancer (Antiangiogenesis, target therapies, HPV?) Section IV: VULVAR CANCER 17. New surgical and medical therapies (Lymphadenectomy, LNS, and plastic surgery) in vulvar cancer Section V: ADDITIONAL 'EDGE' CHAPTERS 18. Fertility and cancer: fertility sparing surgery and cancer in pregnancy
- ISBN: 978-0-12-803741-6
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 336
- Fecha Publicación: 01/03/2017
- Nº Volúmenes: 1
- Idioma: Inglés