Chromatin Signaling and Diseases

Chromatin Signaling and Diseases, Second Edition, a volume in the Translational Epigenetics series, covers the molecular mechanisms that regulate gene expression, which governs embryonic development, growth, and human pathologies associated with aging, such as cancer. Although human genome sequencing continues to improve, molecular mechanisms regulating gene expression remain largely misunderstood. The impact of gene expression defects associated with malfunctioning chromatin signaling are considered in this update. In addition, this new edition has addresses developments in the field, from phase separation of membrane-less organelles and local segregation of factors to chromatinization of naked foreign DNA and cancer evolution as regulated by chromatin signaling.Chromatin signaling proposes that small protein domains recognize chemical modifications on the genome scaffolding histone proteins, facilitating the nucleation of enzymatic complexes at specific loci that then open up or shut down the access to genetic information, thereby regulating gene expression. The addition and removal of chemical modifications on histones, as well as the proteins that specifically recognize these are also considered. Educates clinicians and researchers about chromatin signaling, a molecular mechanism that is changing our understanding of human pathologyExplores the addition and removal of chemical modifications on histones, the proteins that specifically recognize these, and the impact of gene expression defects associated with malfunctioning chromatin signalingAddresses new and evolving topics in the field, including the chromatinization of naked foreign DNA, phase separation and chromatin, and chromatin signaling and cancer evolutionIncludes chapter contributions from leading international researchers in the field INDICE: Section I: Histone Mark Writers1. Histone Acetyltransferases, Key Writers of the Epigenetic Language2. Impacts of Histone Lysine Methylation on Chromatin3. The Role of Histone Mark Writers in Chromatin Signaling: Protein Arginine Methyltransferases4. Histone Kinases and PhosphatasesSection II: Histone Mark Readers5. The Bromodomain as an Acetyl-Lysine Reader Domain6. Chromo Domain Proteins7. The Role of PHD Fingers in Chromatin Signaling: Mechanisms and Functional Consequences of the Recognition of Histone and Non-histone Targets8. Tudor Domains as Methyl-Lysine and Methyl-Arginine ReadersSection III: Histone Mark Erasers9. Histone Deacetylases, the Erasers of the Code10. Lysine Demethylases: Structure, Function, and DisfunctionSection IV: Chromatin Signaling11. Variation, Modification, and Reorganization of Broken Chromatin12. Crosstalk Between Histone Modifications Integrates Various Signaling Inputs to Fine-Tune Transcriptional Output13. Signaling and Chromatin Networks in Cancer BiologySection V: Chromatin Dynamics in Normal and Disease Conditions14. Crosstalk Between DNA Methylation and Chromatin Structure15. Epigenetic Regulation of Endoplasmic Reticulum Stress16. Chromatin Signaling in Aging and Cellular Senescence17. Chromatin Dynamics and Epigenetics of Stem Cells and Stem-Like Cancer Cells18. Altered Chromatin Signaling in Cancer19. Impact of Chromatin Changes in Pathogenesis of Infectious Diseases: A Pathogen View20. Chromatin Remodeling and Epigenetic Reprogramming in Chronic Disease and Cancer in the Liver and Pancreas21. Pharmacological and Therapeutic Targeting of Epigenetic Regulators22. Use of Chromatin Changes as Biomarkers23. Regulation of Host Chromatin by Bacterial Metabolites25. Phase separation and chromatin26. Cancer evolution

• ISBN: 978-0-443-19001-8
• Editorial: Academic Press
• Encuadernacion: Rústica
• Páginas: 480
• Fecha Publicación: 01/03/2025
• Nº Volúmenes: 1
• Idioma: Inglés