Smart Organ-on-Chip Devices discusses the concepts to engineer functional stimuli responsive organotypic-on-chip devices and its application in several fields, including drug development, disease modeling, personalized medicine, and tissue engineering. Groundbreaking studies are presented throughout the book sections to reinforce the importance of adding more reliable and robust in vitro platforms able to closely emulate the dynamism of human physiology. The authors present new information regarding in silico studies of cell spheroids within microfluidic devices, as well as step-by-step guidance on key procedures. Written for researchers, practitioners and students using microfluidic devices as platforms, by well-respected scientists from both academia and industry. Presents the physiological relevance of in vitro tissue-like modelsIntroduces evidence that stimuli-responsive organotypic-on-chip devices are the next generationProvides latest achievements to attain an organ-on-chip device, as well as case studies INDICE: Section 1 - Microfluidics and Organ-on-chip Technologies1. Organotypic on-chip models: Bridging the gap between traditional in vitro culture and animal testing2. Microfabrication processes for the manufacturing of smart organ-on-chip devices3. Bioprinted organ-on-a-chip: A strategy to achieve humanized in vitro models4. Disease modeling and developmental biology through microfluidic channelsSection 2 - Stimuli Active Organotypic-on-chip Devices5. Pathological conditions of mechanobiology: How microfluidic devices are helping to understand the role of mechano-stimuli in oncology6. Mechanically active organotypic-on-chip devices for dynamic cell culture7. Sensors within microfluidic chips: optofluidics to explore in vitro organoid behavior8. Photothermal and magnetic cell stimuli cause by nanoparticles inside organ-on-chip platformsSection 3 - Microphysiological Case Studies9. Brain-on-chip microplatforms for precision medicine, disease modeling, and developmental biology10. Dynamic mircophysiological systems to access sickle cell disease - a case study for disease modeling11. Engineered microfluidic systems for mimicking signaling cascades in continuous-flow cell culture12. Mechanically active heart-on-a-chip: toward a reliable heart beating study model13. Remaining challenges: Are we close to a physiologically representative in vitro model for clinical deployment?
- ISBN: 978-0-443-13403-6
- Editorial: Academic Press
- Encuadernacion: Rústica
- Páginas: 250
- Fecha Publicación: 01/03/2025
- Nº Volúmenes: 1
- Idioma: Inglés