Brain Edema: From Molecular Mechanisms to Clinical Practice

Brain Edema: From Molecular Mechanisms to Clinical Practice brings together the most widely recognized experts in experimental and clinical brain edema research to review the current knowledge gathered on the molecular and cellular pathophysiology and clinical management of brain edema. This timely book also discusses future directions of research and treatment. Brain edema is an integral and acutely life-threatening part of the pathophysiology of multiple cerebral and non-cerebral disorders, including traumatic brain injury, cerebral ischemia, brain tumors, cardiac arrest, altitude sickness and liver failure. Affecting millions worldwide, research over the past few years has shown that a plethora of complex molecular and cellular mechanisms contribute to this pathological accumulation of water in the brain parenchyma. In parallel, the development of new neuroimaging tools has provided a new way to examine how edema develops longitudinally and in real time, both in pre-clinical models and in patients. Despite intense research over the past few decades, therapeutic options are still limited and sometimes not effective. Presents a comprehensive understanding of the molecular mechanisms involved in edema formation and resolutionDiscusses the specific role of edema development in several pathologies, including traumatic brain injury, stroke, brain tumors, cardiac arrest, and liver failure Proposes a new classification of edema based on molecular processesDiscusses clinical management of new clinical trials coming from pre-clinical studiesAddresses the possible link between edema formation, other molecular and cellular processes, including inflammation and neuroinflammation INDICE: Introduction: Brain edema formation - significance for patient outcome Section 1. General Introduction 1. Physiology of cerebral blood vessels 2. Blood-brain interfaces organization in relation to inorganic anion transport, CSF secretion and circulation Section 2. Techniques to investigate cerebral blood 3. Imaging techniques for brain edema: from basic science to the clinic 4. Experimental techniques to investigate the formation of brain edema in vivo 5. In Vitro Models of the Blood-Brain Barrier to Better Understand the Pathophysiology of Brain Edema Section 3. Molecular basis and concepts in brain edema formation for new treatment development 6. The extracellular and perivascular spaces of the brain 7. Blood brain barrier mechanisms of edema formation:  The role of ion transporters and channels 8. Mechanisms of cell volume regulation in the central nervous system 9. Role of aquaporins for the formation and resolution of brain edema 10. Sur1-Trpm4 - promising target for brain edema treatment 11. Role of Matrix Metalloproteinases in Brain Edema Section 4. Brain edema process in pre-clinical models 12. Edema and BBB Breakdown in Stroke 13. Brain edema formation in traumatic brain injury 14. Spinal cord edema after spinal cord injury: From pathogenesis to management 15. Brain Edema in Acute Liver Failure 16. Blood-Brain Barrier and Edema in Brain Tumors 17. Water homeostasis dysfunction in epilepsy  18. Water homeostasis dysfunctions and edema in neuroinflammatory disease 19. Experimental therapies for brain edema and intracranial hypertension Section 5. Clinical features and management of brain edema 20. Clinical monitoring of brain edema 21. Brain edema in developing brain diseases 22. Cerebral edema in cerebrovascular diseases 23. Traumatic brain injury and edema treatment 24. Treatment of edema formation in oncology 25. Perspectives on future translational research on brain edema  

• ISBN: 978-0-12-803196-4
• Editorial: Academic Press
• Encuadernacion: Cartoné
• Páginas: 600
• Fecha Publicación: 01/09/2017
• Nº Volúmenes: 1
• Idioma: Inglés