Body-on-a-Chip: Essentials and Applications provides the reader high-quality information, in a single resource, that is necessary to explore the use of BOC systems from design and development to testing and personalized medicine, to medical research and diagnostics. BOC systems can recapitulate native tissue/ organ architecture, diffusion kinetics of drugs physiological flow conditions etc., similar to what would happen in the body, they are particularly powerful in predicting human efficacy prior to clinical testing of a drug, determining potential toxicity, or in clinical studies to test underlying mechanisms or action or adverse effects. With recent advancements in high-throughput analysis systems and artificial intelligence, it has also become possible to screen several drugs at a time. Covers design, applications, and future of this new generation technologyProvides a valuable resource for students, educators, scientists/researchers, and clinicians to use for education, research and exploring real world scenariosWritten by the world’s most prominent experts in the field INDICE: 1. The Concept of Organ-on-a-Chip and Body-on-a-Chip Devices 2. Advances in Three-Dimensional Cell Culture 3. Organoids and Spheroids 4. Microfluidics 5. Materials for fabricating Micro-physiological Systems 6. Design and Engineering of Multi-organ Systems 7. Recent Trends in Microfluidic Platforms for Body-on-a-chip systems 8. Chapter Microfabrication Techniques for Making Organ-on-a-Chip and Body-on-a-Chip Devices 9. Combining 3D bioprinting with organ-on-a-chip technology 10. Incorporating Biological Components within Organ-on-a-Chip and Body-on-a-Chip Systems 11. On-chip Sensing and Data Analysis from Multi-organ Systems 12. Liver-on-a-chip 13. Lung-on-a-chip 14. Lung-on-a-chip As a Model for Studying Effects of Cigarette Smoke 15. Kidney-on-a-chip 16. Adrenals-on-a-Chip 17. Heart-on-a-chip 18. Pancreas-on-a-Chip 19. Spleen-on-a-Chip 20. Skin-on-a-Chip 21. Blood Vessels-on-a-Chip 22. Bone-on-a-Chip 23. Cartilage-on-a-Chip 24. Muscle-on-a-Chip 25. Bladder-on-a-Chip 26. Testis-on-a-Chip 27. Ovary-on-a-chip 28. Thyroid-on-a-Chip 29. Thymus-on-a-Chip 30. Brain-on-a-Chip 31. Salivary glands-on-a-Chip 32. Bone marrow on a Chip 33. Human Organ-on-a-Chip Models for Diseases 34. Cancer-on-a-Chip 35. Modeling Disease Pathogenesis Using Organ-on-a-chip Platforms 36. Organ-on-a-chip using stem cells 37. Role of Body-on-a-chip Technology in Drug Discovery and Development 38. Computational Pharmacokinetic Modeling of Body-on-chip Devices 39. Drug and Toxicity Screening Using Multi-organ Systems 40. Micro-physiological Systems for Screening Environmental Toxins and Pollutants 41. Challenges in Manufacturing and Commercial Use of Body-on-a-chip and other Micro-physiological Devices 42. Body-on-chip Devices and the Regulatory Agencies 43. Body-on-chip Systems and Clinical Biomarkers Discovery 44. Body-on-chip Systems and chemical agents 45. Body-on-chip Systems and viral agents 46. Body-on-chip Systems and omics 47. Body-on-chip Systems and artificial intelligence- pathways for the future
- ISBN: 978-0-443-16110-0
- Editorial: Academic Press
- Encuadernacion: Cartoné
- Páginas: 500
- Fecha Publicación: 01/06/2025
- Nº Volúmenes: 1
- Idioma: Inglés